Quetiapine (Seroquel) and your teeth

Quetiapine is an atypical antipsychotic used for schizophrenia, bipolar disorder, and as an off-label sleep aid and depression adjunct.

Quetiapine causes substantial dry mouth at therapeutic doses, mediated through anticholinergic and histamine receptor effects. Off-label use as a sleep aid is increasingly common, which means many patients take it nightly even though they do not have schizophrenia or bipolar disorder. The nightly bedtime dosing puts the dry mouth effect right in the overnight window when saliva is naturally lowest, similar to Benadryl.